The effect of two- and five—component membranes on the cartilage regeneration rate in the experiment. Substantiate of the laboratory animals rational choice for the experiment

Introduction: chondral and osteochondral articular cartilage defects is a significant clinical pathology affecting young, employable population. It's necessary to develop clinical efficacy domestic constructs.

Purpose: to examine the effect of two- and five-component membranes on the properties and rate of cartilage regeneration in the experiment. A literary research was carried out to substantiate the rational choice of experimental animals and the experimental cartilage defects characteristics.

Materials and methods: prospective experimental pilot research. Two study groups were formed (n=13), osteochondral defect models of the rat femur articular surface were surgically created and replaced with two- and five-component membranes developed by Sechenov University. The macroscopic and histological evaluation were performed after euthanasia in terms of 7, 30, 60, 120 days. The defects depth and average value were evaluated at each term. Change of defects depth was measured at each term, the cell density in regenerates was calculated.

Results: both membranes were therapeutically efficacious in the replacement of defects, there was noticed the formation of fibrous cartilage tissue.

Conclusion: the clinical result is satisfactory, further improvement direction of these constructs can be associated with MACI method.

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