Parenteral administration of tranexamic acid in total hip joint endoprosthesis

Tranexamic acid can be used to treat postoperative bleeding after total hip endoprosthesis surgery. The relevance of this study is determined by the need to conduct research to identify the most effective and safe method of administering the drug.

Objective: The aim of this work is to propose a simplified and optimal method of «Tranexam» usage.

Materials and methods: A prospective study was conducted on 120 patients who underwent primary unilateral total hip endoprosthesis. The patients were divided into two groups. Patients from the first group were administered with tranexamic acid according to the proposed method, which is to parenterally administer tranexamic acid in a fixed dose of 1000 mg not earlier than 30 minutes and not later than 1 hour before the surgery, then later optionally administer the drug while not exceeding the dosage of 2000 mg. The second group consisted of patients who were not administered with tranexamic acid.

Results: Comparison of the two groups provided strong evidence for the use of tranexamic acid.

Conclusions: The study showed that usage of tranexamic acid significantly reduces the risk of increased blood loss and does not increase the risk of thromboembolic complications when administered parenterally according to the method proposed in this study.

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